Factor V Leiden is a blood clotting disorder that affects roughly 5% of the female population. And me.
I had to go to the doctor's yesterday morning to pick up some documentation for the insurance thing we're fighting. I was also getting antsy to hear from the doctor on what the blood work showed, so I stopped by to see her.
She sat me down in her office and went to get her computer. I was starting to panic because I was convinced she was going to tell me something horrible like I was HIV+, but I've always been a one-man kinda gal, and thought that was pretty unlikely since I'd been tested for it in the past. Still, why wouldn't she let a nurse give me the results?
The computer took forever to boot up and she kept swearing at it and I kept getting more and more nervous.
Finally Old Bessie did its thing, and she started talking to me about C and S proteins and I was wishing I'd spent more time listening in Mr. Schnoebelen's chemistry class instead of spending the entire time trying to unsucessfully flirt with a football player. (The "C" grade didn't help matters much, either, as I think I forgot to pay attention somewhere between NaCl and Bromide.)
Anyway, where were we? Ah, yes...she said that my S protein was low, but since I have been recently pregnant, she'll have to test that again. She said the S protein usually goes back up after pregnancy has been over for awhile. If S protein is still low, it means I have a clotting disorder completely unrelated to the Factor V Leiden.
Then she said, the other thing you tested positive for was one mutation of the gene for Factor V Leiden. In my head I thought, "So much makes sense now." Factor V Leiden is a condition in which the blood clots TOO much. 5% of women have this gene, and if you have it you can't be on birth control or any other sort of medication that causes your blood to clot, because if it clots, you can end up with a blood clot in your lungs or brain that would kill you.
During pregnancy, many women with Factor V Leiden can suffer from recurrent miscarriages and stillbirth. The reason for the stillbirth is that Factor V Leiden can interfere with the blood passage between the placenta and the uterine wall, causing the blood to clot when it should be flowing freely. It's not as well-documented on how it could cause miscarriage in the early weeks, since there is no placenta doing any job then, but from what I've read, any child I have has a 50% chance of inheriting this characteristic from me. If a child I'm carrying has the gene as well, they may miscarry unless I am taking something that thins my blood.
The jaw-dropping thing about all of this is this: remember when I was absolutely crazy for Asher to be born early? I mean, even more so than when I was having Lucy, and she was the one with the birth defects? Well, my doctor explained that had I NOT had him early, he could easily have been stillborn. The placenta clots with Factor V Leiden, especially in late stages of pregnancy, if the woman's blood isn't being properly thinned. Or, the placenta tears away from the uterine wall. So, the fact that I was psychotic about getting him out MAY HAVE BEEN THE THING THAT SAVED HIM.
Mother's intuition? OCD? Who knows.
The even crazier thing is this: In the pathology reports we received regarding the placentas of Lucy and her twin, there was discovery made that in each placenta, there was unusual/abnormal blood clotting. The pathologist at the time stated that each baby was getting about 75% of the vital blood/nutrients/oxygen he or she was normally supposed to get.
Are you following?
I tell people about the diagnosis and I will hear, "I'm sorry." You know what? I'm not sorry at all. To have an "explanation"? It's wonderful. Sure, it doesn't change anything. Lucy still has her birth defects and I have still lost 5 babies. But to know that I am extremely lucky to have two living children with an untreated Factor V Leiden diagnosis? That is really something. Having this new piece of information has really turned this whole thing on its head from, "I've lost four babies" to, "Logically, I really shouldn't have any." Just kind of humbling, I guess.
"I hope you realize how lucky you are to have had the outcomes that you have had with this blood clotting condition," the doctor said. She told me how she's had many cases where they didn't know Factor V Leiden was present and babies were stillborn...and mothers can die. She was surprised the clotting didn't totally clot off Lucy's placenta and cause even more damage.
OK, so here's the solution...from what I understand, and depending on the severity with which I have it, I would either take a baby aspirin a day to thin my blood (I know, crazy, right?), or I would have to take Heparin (a blood thinner) shots during my pregnancy.
So, a pregnancy is possible.
It's just so crazy to have answers!
Am I missing anything? Anyone have any other information I missed? I'm still trying to sort all of this out.
As far as I know, no HIV+.